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Background: Clinical genomic implementation studies pose challenges for informed consent. Consent forms often include complex language and concepts, which can be a barrier to diverse enrollment, and these studies often blur traditional research-clinical boundaries. There is a move toward self-directed, web-based research enrollment, but more evidence is needed about how these enrollment approaches work in practice. In this study, we developed and evaluated a literacy-focused, web-based consent approach to support enrollment of diverse participants in an ongoing clinical genomic implementation study. (...) Methods: As part of the Cancer Health Assessments Reaching Many (CHARM) study, we developed a web-based consent approach that featured plain language, multimedia, and separate descriptions of clinical care and research activities. CHARM offered clinical exome sequencing to individuals at high risk of hereditary cancer. We interviewed CHARM participants about their reactions to the consent approach. We audio recorded, transcribed, and coded interviews using a deductively and inductively derived codebook. We reviewed coded excerpts as a team to identify overarching themes. Results: We conducted 32 interviews, including 12 (38%) in Spanish. Most (69%) enrolled without assistance from study staff, usually on a mobile phone. Those who completed enrollment in one day spent an average of 12 minutes on the consent portion. Interviewees found the information simple to read but comprehensive, were neutral to positive about the multimedia support, and identified increased access to testing in the study as the key difference from clinical care. Conclusions: This study showed that interviewees found our literacy-focused, web-based consent approach acceptable; did not distinguish the consent materials from other online study processes; and valued getting access to testing in the study. Overall, conducting empirical bioethics research in an ongoing clinical trial was useful to demonstrate the acceptability of our novel consent approach but posed practical challenges. (shrink)

This long-awaited new edition contains eight of the dialogues of Plato, and is the first in a new five-volume complete edition of his works in the OCT series.

Best known for reviving the tradition of classical liberalism, F. A. Hayek was also a prominent scholar of the philosopher John Stuart Mill. One of his greatest undertakings was a collection of Mill’s extensive correspondence with his longstanding friend and later companion and wife, Harriet Taylor-Mill. Hayek first published the Mill-Taylor correspondence in 1951, and his edition soon became required reading for any study of the nineteenth-century foundations of liberalism. This latest addition to the University of Chicago Press’s Collected Works (...) of F. A. Hayek series showcases the fascinating intersections between two of the most prominent thinkers from two successive centuries. Hayek situates Mill within the complex social and intellectual milieu of nineteenth-century Europe—as well as within twentieth-century debates on socialism and planning—and uncovers the influence of Taylor-Mill on Mill’s political economy. The volume features the Mill-Taylor correspondence and brings together for the first time Hayek’s related writings, which were widely credited with beginning a new era of Mill scholarship. (shrink)

Abstract: This paper conceptualizes the interaction of three discursive paths: the history of science, scientific education, and the debate about the Filipinization of scientific education. The paper analyzes the form of scientific revolution in the field of medicine which is different from its counterparts in the fields of astronomy and physics; as such, the paper contributes a particular narrative of that provides proof that it is possible to tackle scientific issues using the Filipino language as medium. It assumes that the (...) Filipino language should be used in the teaching of science and in scientific research. The scientific revolution in medicine is seen as the eventual downfall of Hippocrates and Galen and the rise of the theories of Paracelsus, Vesalius, Fracastoro , and Harvey. (shrink)

L'étude aborde la question de la méthode théologique, en considérant sa nature et sa typologie, ses possibilités et ses limites, ainsi que les conditions de sa légitimité devant les instances du «depositum fidei». On attribue une importance spéciale à la tension de fond entre l'usage de la méthode kérygmatique et de la méthode dialogale dans la théologie du passé, mais surtout dans le débat actuel, spécialement entre divers courants de la théologie de la transcendance, telles les «théologies de la parole» (...) et la «méthode de corrélation», ou encore entre les «théologies du mystère» et la «méthode transcendantale». Pareille tension s'aggrave dans les «théologies de l'immanence», telles les théologies de la «mort de Dieu» ou les «théologies de l'histoire», ou entre les «théologies de la modernité» et certaines «théologies de la praxis». A la fin de ce panorama du pluralisme méthodologique actuel, on formule certains principes fondamentaux sur le problème débattu. Finalement, on considère le caractère obligatoire du «depositum fidei» comme instance théologique définitive. (shrink)